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Denosumab for Type 1 Diabetes (NCT06524960)
A Study of TAR-200 Versus Intravesical Chemotherapy in Participants With Recurrent High-Risk Non-Muscle-Invasive Bladder Cancer (HR-NMIBC) After Bacillus Calmette-Guérin (BCG) (NCT06211764)
Saruparib (AZD5305) vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents (NCT06120491)
A Study of Adjuvant Cretostimogene Grenadenorepvec for Treatment of Intermediate Risk NMIBC Following TURBT [PIVOT-006] (NCT06111235)
Prospective Database Registry Study of Scoliosis in Children With Cerebral Palsy (NCT00680264)
Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10) (NCT04793958)
Study to Assess the Efficacy, Safety, and Tolerability of Valbenazine for the Treatment of Dyskinesia Due to Cerebral Palsy (NCT05206513)
Lp(a) Lowering Study of Pelacarsen (TQJ230) in US Black/African American and Hispanic Participants With Elevated Lp(a) and Established ASCVD (NCT06267560)
Study of Patritumab Deruxtecan Plus Pembrolizumab With Other Anticancer Agents in Participants With High-Risk Early-Stage Triple-Negative or Hormone Receptor-Low Positive/HER-2 Negative Breast Cancer (MK-1022-010, HERTHENA-Breast-03) (NCT06797635)
Phase 2 Study to Evaluate Safety and Efficacy of Cretostimogene Grenadenorepvec in High-Risk NMIBC [CORE-008] (NCT06567743)
Randomized, Double-blind, Placebo-controlled, Crossover Study of Atrasentan in Subjects With IgA Nephropathy (NCT05834738)
A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer (NCT06319820)
A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004) (NCT06136650)
DISCERN: Dual Versus Single ICB in PDL-1 Negative NSCLC (NCT06364917)
A Study to Learn About How Well BAY3283142 Works and Its Safety in Participants With Chronic Kidney Disease (NCT06522997)
Horizon Adaptive Platform Trial Evaluating Therapies in RRMM (NCT06171685)
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{"patient":{"resourceType":"Patient","id":"NCT06524960-3","extension":[{"url":"http://hl7.org/fhir/StructureDefinition/us-core-race","valueCodeableConcept":{"coding":[{"system":"http://hl7.org/fhir/v3/Race","code":"2106-3","display":"White"}]}},{"url":"http://hl7.org/fhir/StructureDefinition/us-core-ethnicity","valueCodeableConcept":{"coding":[{"system":"http://hl7.org/fhir/v3/Ethnicity","code":"2186-5","display":"Non-Hispanic"}]}}],"identifier":[{"use":"usual","system":"http://example.org/patients","value":"123456789"}],"name":[{"use":"official","family":"Harris","given":["Donna"]}],"telecom":[{"system":"phone","value":"555-123-4567","use":"home"},{"system":"email","value":"donna.harris@example.com","use":"home"}],"gender":"female","birthDate":"1985-06-15","address":[{"use":"home","line":["123 Elm Street"],"city":"Springfield","state":"IL","postalCode":"62701","country":"USA"}],"maritalStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/v3-MaritalStatus","code":"M","display":"Married"}]},"communication":[{"language":{"coding":[{"system":"urn:ietf:bcp:47","code":"en","display":"English"}]},"preferred":true}]},"fhirResources":[{"resourceType":"Condition","id":"NCT06524960-3-0","clinicalStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/condition-clinical","code":"active","display":"Active"}]},"verificationStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/condition-ver-status","code":"confirmed","display":"Confirmed"}]},"code":{"coding":[{"system":"http://snomed.info/sct","code":"46635009","display":"Type 1 diabetes mellitus"}]},"subject":{"reference":"Patient/NCT06524960-3"},"onsetDateTime":"2010-05-01"},{"resourceType":"Observation","id":"NCT06524960-3-1","status":"final","code":{"coding":[{"system":"http://loinc.org","code":"2028-9","display":"C-peptide [Mass/volume] in Serum or Plasma"}]},"subject":{"reference":"Patient/NCT06524960-3"},"effectiveDateTime":"2023-09-15","valueQuantity":{"value":0.3,"unit":"nmol/L","system":"http://unitsofmeasure.org","code":"nmol/L"}},{"resourceType":"Observation","id":"NCT06524960-3-2","status":"final","code":{"coding":[{"system":"http://loinc.org","code":"4548-4","display":"Hemoglobin A1c/Hemoglobin.total in Blood"}]},"subject":{"reference":"Patient/NCT06524960-3"},"effectiveDateTime":"2023-09-15","valueQuantity":{"value":8.7,"unit":"%","system":"http://unitsofmeasure.org","code":"%"}},{"resourceType":"MedicationStatement","id":"NCT06524960-3-3","status":"active","subject":{"reference":"Patient/NCT06524960-3"},"effectivePeriod":{"start":"2010-05-01"}}],"patientNote":"Patient is a 38-year-old female with a history of type 1 diabetes diagnosed approximately 3 years ago. She has been managing her condition with insulin therapy and reports generally stable blood glucose levels, although she occasionally experiences mild hypoglycemic episodes. Her recent HbA1c was measured at 8.7%, indicating suboptimal glycemic control. Patient has a BMI of 29 kg/m2, which is within the acceptable range for her height and weight. She denies any recent episodes of severe hypoglycemia or diabetic ketoacidosis. Patient is currently taking insulin and has not used any other diabetes medications in the past three months. She reports feeling fatigued and has noticed some difficulty concentrating, which she attributes to her fluctuating blood sugar levels. Her C-peptide levels were measured at 0.3 nmol/L, suggesting some residual beta cell function. Patient is married and lives with her husband and two children. She is fluent in English and prefers to communicate in this language during medical consultations. Overall, she is motivated to improve her diabetes management and is interested in exploring new treatment options.","grade":"Disqualified"}
{"patient":{"resourceType":"Patient","id":"NCT06524960-1","identifier":[{"use":"usual","system":"http://example.org/patients","value":"123456789"}],"name":[{"use":"official","family":"Lopez","given":["Donald"]}],"telecom":[{"system":"phone","value":"555-123-4567","use":"home"},{"system":"email","value":"donald.lopez@example.com","use":"home"}],"gender":"male","birthDate":"1975-06-15","address":[{"use":"home","line":["123 Elm Street"],"city":"Springfield","state":"IL","postalCode":"62704","country":"USA"}],"maritalStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/v3-MaritalStatus","code":"M","display":"Married"}]},"communication":[{"language":{"coding":[{"system":"urn:ietf:bcp:47","code":"en","display":"English"}]},"preferred":true}]},"fhirResources":[{"resourceType":"Condition","id":"NCT06524960-1-0","clinicalStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/condition-clinical","code":"active"}]},"code":{"coding":[{"system":"http://snomed.info/sct","code":"46635009","display":"Type 1 diabetes mellitus"}],"text":"Type 1 diabetes mellitus"},"subject":{"reference":"Patient/NCT06524960-1"}},{"resourceType":"Observation","id":"NCT06524960-1-1","code":{"coding":[{"system":"http://loinc.org","code":"4548-4","display":"Hemoglobin A1c/Hemoglobin.total in Blood"}],"text":"HbA1c"},"subject":{"reference":"Patient/NCT06524960-1"},"valueQuantity":{"value":9.8,"unit":"%","system":"http://unitsofmeasure.org","code":"%"}},{"resourceType":"Observation","id":"NCT06524960-1-2","code":{"coding":[{"system":"http://loinc.org","code":"2021-9","display":"C-Peptide [Mass/volume] in Serum or Plasma"}],"text":"C-Peptide"},"subject":{"reference":"Patient/NCT06524960-1"},"valueQuantity":{"value":0.3,"unit":"ng/mL","system":"http://unitsofmeasure.org","code":"ng/mL"}},{"resourceType":"MedicationStatement","id":"NCT06524960-1-3","status":"active","subject":{"reference":"Patient/NCT06524960-1"}}],"patientNote":"Patient is a 48-year-old male with a long-standing history of type 1 diabetes mellitus. He reports frequent episodes of hyperglycemia, with recent HbA1c levels recorded at 9.8%, indicating suboptimal glycemic control. Despite adherence to an insulin regimen, including Insulin Glargine, the patient struggles with maintaining target blood glucose levels. He denies any recent episodes of severe hypoglycemia or diabetic ketoacidosis. The patient has a BMI of 33 kg/m2, which is above the recommended range, and he has been advised to engage in a weight management program. He has a history of hypertension, currently managed with Lisinopril, and reports no adverse effects from this medication. The patient is married and lives with his spouse, who is supportive of his health management efforts. He is fluent in English and prefers to communicate in this language during medical consultations. The patient is motivated to improve his health outcomes and is interested in exploring new treatment options to better manage his diabetes. He has no known drug allergies and has been taking metformin for the past three months. The patient is scheduled for a follow-up appointment in three months to reassess his diabetes management plan.","grade":"Qualified"}
{"patient":{"resourceType":"Patient","id":"NCT06524960-2","extension":[{"url":"http://hl7.org/fhir/StructureDefinition/us-core-ethnicity","valueCodeableConcept":{"coding":[{"system":"http://hl7.org/fhir/v3/Ethnicity","code":"2135-2","display":"Hispanic or Latino"}]}},{"url":"http://hl7.org/fhir/StructureDefinition/us-core-race","valueCodeableConcept":{"coding":[{"system":"http://hl7.org/fhir/v3/Race","code":"2106-3","display":"White"}]}}],"identifier":[{"use":"usual","system":"http://example.org/patients","value":"JS123456"}],"name":[{"use":"official","family":"Smith","given":["Jessica"]}],"telecom":[{"system":"phone","value":"555-123-4567","use":"home"},{"system":"email","value":"jessica.smith@example.com","use":"home"}],"gender":"female","birthDate":"1990-05-15","address":[{"use":"home","line":["123 Maple Street"],"city":"Springfield","state":"IL","postalCode":"62704","country":"USA"}],"maritalStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/v3-MaritalStatus","code":"M","display":"Married"}]},"communication":[{"language":{"coding":[{"system":"urn:ietf:bcp:47","code":"en","display":"English"}]},"preferred":true}]},"fhirResources":[{"resourceType":"Condition","id":"NCT06524960-2-0","clinicalStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/condition-clinical","code":"active","display":"Active"}]},"verificationStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/condition-ver-status","code":"confirmed","display":"Confirmed"}]},"code":{"coding":[{"system":"http://snomed.info/sct","code":"46635009","display":"Type 1 diabetes mellitus"}]},"subject":{"reference":"Patient/NCT06524960-2"},"onsetDateTime":"2010-06-01"},{"resourceType":"Observation","id":"NCT06524960-2-1","status":"final","code":{"coding":[{"system":"http://loinc.org","code":"1988-5","display":"C-peptide [Mass/volume] in Serum or Plasma"}]},"subject":{"reference":"Patient/NCT06524960-2"},"effectiveDateTime":"2023-09-15","valueQuantity":{"value":0.7,"unit":"ng/mL","system":"http://unitsofmeasure.org","code":"ng/mL"}},{"resourceType":"Observation","id":"NCT06524960-2-2","status":"final","code":{"coding":[{"system":"http://loinc.org","code":"4548-4","display":"Hemoglobin A1c/Hemoglobin.total in Blood"}]},"subject":{"reference":"Patient/NCT06524960-2"},"effectiveDateTime":"2023-09-15","valueQuantity":{"value":7.8,"unit":"%","system":"http://unitsofmeasure.org","code":"%"}},{"resourceType":"MedicationStatement","id":"NCT06524960-2-3","status":"active","subject":{"reference":"Patient/NCT06524960-2"},"effectivePeriod":{"start":"2010-06-01"}}],"patientNote":"Patient is a 33-year-old female with a history of type 1 diabetes diagnosed 13 years ago. She has been managing her condition with insulin therapy and reports good adherence to her regimen. Her recent lab results show a C-peptide level of 0.7 ng/mL, indicating some residual beta cell function. The HbA1c level is 7.8%, which is above the target but manageable with current treatment. Patient denies any recent episodes of severe hypoglycemia or diabetic ketoacidosis. She has a BMI of 28 kg/m2, which is within the acceptable range for her age and height. Patient reports occasional fatigue and mild joint pain, which she attributes to her busy lifestyle and work as a school teacher. She is married and has two children, which she states are her primary motivation for maintaining her health. Patient is fluent in English and prefers communication in this language. She has no known allergies and her vaccination status is up to date. During the visit, she expressed interest in exploring new treatment options to improve her glycemic control and reduce the risk of long-term complications associated with diabetes.","grade":"Qualified"}
{"patient":{"resourceType":"Patient","id":"NCT06524960-4","extension":[{"url":"http://hl7.org/fhir/StructureDefinition/us-core-ethnicity","valueCodeableConcept":{"coding":[{"system":"http://hl7.org/fhir/v3/Race","code":"2106-3","display":"White"}]}},{"url":"http://hl7.org/fhir/StructureDefinition/us-core-race","valueCodeableConcept":{"coding":[{"system":"http://hl7.org/fhir/v3/Ethnicity","code":"2135-2","display":"Hispanic or Latino"}]}}],"identifier":[{"use":"usual","system":"http://example.org/patients","value":"JG123456"}],"name":[{"use":"official","family":"Gonzalez","given":["Joshua"]}],"telecom":[{"system":"phone","value":"555-123-4567","use":"home"},{"system":"email","value":"joshua.gonzalez@example.com","use":"home"}],"gender":"male","birthDate":"1995-06-15","address":[{"use":"home","line":["123 Elm Street"],"city":"Springfield","state":"IL","postalCode":"62704","country":"USA"}],"maritalStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/v3-MaritalStatus","code":"M","display":"Married"}]},"communication":[{"language":{"coding":[{"system":"urn:ietf:bcp:47","code":"en","display":"English"}]},"preferred":true}]},"fhirResources":[{"resourceType":"Condition","id":"NCT06524960-4-0","clinicalStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/condition-clinical","code":"active","display":"Active"}]},"verificationStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/condition-verification","code":"confirmed","display":"Confirmed"}]},"code":{"coding":[{"system":"http://snomed.info/sct","code":"46635009","display":"Type 1 diabetes mellitus"}]},"subject":{"reference":"Patient/NCT06524960-4"},"onsetDateTime":"2015-08-01"},{"resourceType":"Observation","id":"NCT06524960-4-1","status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory","display":"Laboratory"}]}],"code":{"coding":[{"system":"http://loinc.org","code":"1988-5","display":"C-peptide [Mass/volume] in Serum or Plasma"}]},"subject":{"reference":"Patient/NCT06524960-4"},"effectiveDateTime":"2023-10-01","valueQuantity":{"value":0.7,"unit":"ng/mL","system":"http://unitsofmeasure.org","code":"ng/mL"}},{"resourceType":"Observation","id":"NCT06524960-4-2","status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory","display":"Laboratory"}]}],"code":{"coding":[{"system":"http://loinc.org","code":"4548-4","display":"Hemoglobin A1c/Hemoglobin.total in Blood"}]},"subject":{"reference":"Patient/NCT06524960-4"},"effectiveDateTime":"2023-10-01","valueQuantity":{"value":7.2,"unit":"%","system":"http://unitsofmeasure.org","code":"%"}},{"resourceType":"MedicationStatement","id":"NCT06524960-4-3","status":"active","subject":{"reference":"Patient/NCT06524960-4"},"effectivePeriod":{"start":"2015-08-01"}}],"patientNote":"Patient is a 28-year-old male with a history of type 1 diabetes diagnosed approximately eight years ago. He has been managing his condition with insulin therapy and reports good adherence to his treatment regimen. Recent laboratory tests show a C-peptide level of 0.7 ng/mL, indicating some residual beta cell function. His HbA1c is currently at 7.2%, which is within the target range for his age and condition. Patient denies any recent episodes of severe hypoglycemia or diabetic ketoacidosis. He maintains a healthy lifestyle with regular exercise and a balanced diet, contributing to his stable BMI of 24 kg/m2. Patient has no history of using diabetes medications other than insulin in the past three months. He reports occasional mild hypoglycemic episodes, which he manages effectively with dietary adjustments. Patient is married and lives with his spouse, who is supportive of his health management. He expresses interest in exploring new treatment options to further improve his glycemic control. Overall, patient appears motivated and engaged in his diabetes care, with a good understanding of his condition and management strategies.","grade":"Disqualified"}
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