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DISCERN: Dual Versus Single ICB in PDL-1 Negative NSCLC (NCT06364917)
A Study of Adjuvant Cretostimogene Grenadenorepvec for Treatment of Intermediate Risk NMIBC Following TURBT [PIVOT-006] (NCT06111235)
A Study to Learn About How Well BAY3283142 Works and Its Safety in Participants With Chronic Kidney Disease (NCT06522997)
A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer (NCT06319820)
A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004) (NCT06136650)
Randomized, Double-blind, Placebo-controlled, Crossover Study of Atrasentan in Subjects With IgA Nephropathy (NCT05834738)
A Study of TAR-200 Versus Intravesical Chemotherapy in Participants With Recurrent High-Risk Non-Muscle-Invasive Bladder Cancer (HR-NMIBC) After Bacillus Calmette-Guérin (BCG) (NCT06211764)
Prospective Database Registry Study of Scoliosis in Children With Cerebral Palsy (NCT00680264)
Phase 2 Study to Evaluate Safety and Efficacy of Cretostimogene Grenadenorepvec in High-Risk NMIBC [CORE-008] (NCT06567743)
Study of Patritumab Deruxtecan Plus Pembrolizumab With Other Anticancer Agents in Participants With High-Risk Early-Stage Triple-Negative or Hormone Receptor-Low Positive/HER-2 Negative Breast Cancer (MK-1022-010, HERTHENA-Breast-03) (NCT06797635)
Denosumab for Type 1 Diabetes (NCT06524960)
Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10) (NCT04793958)
Study to Assess the Efficacy, Safety, and Tolerability of Valbenazine for the Treatment of Dyskinesia Due to Cerebral Palsy (NCT05206513)
Saruparib (AZD5305) vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents (NCT06120491)
Horizon Adaptive Platform Trial Evaluating Therapies in RRMM (NCT06171685)
A Comparison of Outcomes After Anterior Cruciate Ligament (ACL) or Anterior Cruciate Ligament and Meniscus (ACL+Meniscus) Surgery Using Semiconductor Fabric Products (NCT06979804)
Lp(a) Lowering Study of Pelacarsen (TQJ230) in US Black/African American and Hispanic Participants With Elevated Lp(a) and Established ASCVD (NCT06267560)
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{"patient":{"resourceType":"Patient","id":"NCT06364917-3","extension":[{"url":"http://hl7.org/fhir/StructureDefinition/us-core-ethnicity","valueCodeableConcept":{"coding":[{"system":"http://hl7.org/fhir/v3/Ethnicity","code":"2135-2","display":"Hispanic or Latino"}]}},{"url":"http://hl7.org/fhir/StructureDefinition/us-core-race","valueCodeableConcept":{"coding":[{"system":"http://hl7.org/fhir/v3/Race","code":"2106-3","display":"White"}]}}],"identifier":[{"use":"usual","system":"http://example.org/patients","value":"MR123456"}],"name":[{"use":"official","family":"Rodriguez","given":["Michelle"]}],"telecom":[{"system":"phone","value":"555-123-4567","use":"home"},{"system":"email","value":"michelle.rodriguez@example.com","use":"home"}],"gender":"female","birthDate":"1975-06-15","address":[{"use":"home","line":["123 Elm Street"],"city":"Springfield","state":"IL","postalCode":"62704","country":"USA"}],"maritalStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/v3-MaritalStatus","code":"M","display":"Married"}]},"communication":[{"language":{"coding":[{"system":"urn:ietf:bcp:47","code":"en","display":"English"}]},"preferred":true}]},"fhirResources":[{"resourceType":"Condition","id":"NCT06364917-3-0","clinicalStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/condition-clinical","code":"active","display":"Active"}]},"verificationStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/condition-ver-status","code":"confirmed","display":"Confirmed"}]},"code":{"coding":[{"system":"http://snomed.info/sct","code":"254637007","display":"Non-small cell lung cancer"}]},"subject":{"reference":"Patient/NCT06364917-3"}},{"resourceType":"Observation","id":"NCT06364917-3-1","code":{"coding":[{"system":"http://loinc.org","code":"89243-0","display":"ECOG performance status"}]},"subject":{"reference":"Patient/NCT06364917-3"},"valueCodeableConcept":{"coding":[{"system":"http://snomed.info/sct","code":"0","display":"Fully active"}]}},{"resourceType":"MedicationStatement","id":"NCT06364917-3-2","subject":{"reference":"Patient/NCT06364917-3"},"dosage":[{"text":"5 mg daily"}]}],"patientNote":"Patient is a 48-year-old female with a confirmed diagnosis of stage IV non-small cell lung cancer. She has been experiencing persistent cough and shortness of breath over the past few months. Imaging studies reveal multiple metastatic lesions in the lungs and liver. Patient reports occasional fatigue but maintains a good level of daily activity, consistent with an ECOG performance status of 0. She has a history of seasonal allergies but no known drug allergies. Patient has not received any live-virus vaccinations in the past month. She is currently on a low-dose prednisone regimen for mild asthma, which she has been managing well. Her blood pressure and heart rate are within normal limits, and she denies any recent infections or fever. Patient expresses concern about her prognosis and is interested in exploring treatment options. She has a supportive family and is married with two children. Her primary language is English, and she communicates effectively during consultations.","grade":"Disqualified"}
{"patient":{"resourceType":"Patient","id":"NCT06364917-1","identifier":[{"use":"usual","system":"http://example.org/patients","value":"123456789"}],"name":[{"use":"official","family":"Perez","given":["Charles"]}],"telecom":[{"system":"phone","value":"555-123-4567","use":"home"},{"system":"email","value":"charles.perez@example.com","use":"home"}],"gender":"male","birthDate":"1955-06-15","address":[{"use":"home","line":["123 Main St"],"city":"Springfield","state":"IL","postalCode":"62701","country":"USA"}],"maritalStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/v3-MaritalStatus","code":"M","display":"Married"}]},"communication":[{"language":{"coding":[{"system":"urn:ietf:bcp:47","code":"en","display":"English"}]},"preferred":true}]},"fhirResources":[{"resourceType":"Condition","id":"NCT06364917-1-0","clinicalStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/condition-clinical","code":"active"}]},"verificationStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/condition-ver-status","code":"confirmed"}]},"category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/condition-category","code":"problem-list-item","display":"Problem List Item"}]}],"code":{"coding":[{"system":"http://snomed.info/sct","code":"254637007","display":"Non-small cell lung cancer"}],"text":"Non-small cell lung cancer"},"subject":{"reference":"Patient/NCT06364917-1"},"onsetDateTime":"2023-01-15"},{"resourceType":"Observation","id":"NCT06364917-1-1","status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory","display":"Laboratory"}]}],"code":{"coding":[{"system":"http://loinc.org","code":"1975-2","display":"ECOG performance status"}],"text":"ECOG performance status"},"subject":{"reference":"Patient/NCT06364917-1"},"effectiveDateTime":"2023-10-01","valueCodeableConcept":{"coding":[{"system":"http://loinc.org","code":"LA9623-3","display":"1"}],"text":"ECOG performance status 1"}},{"resourceType":"MedicationStatement","id":"NCT06364917-1-2","status":"active","subject":{"reference":"Patient/NCT06364917-1"},"effectivePeriod":{"start":"2023-09-15","end":"2023-10-01"}}],"patientNote":"Patient is a 68-year-old male with a confirmed diagnosis of stage IV non-small cell lung cancer. He has been experiencing persistent cough and shortness of breath over the past few months. Recent imaging studies show metastasis to the liver and bones. The patient reports significant fatigue and has lost approximately 10 pounds in the last two months. He has a history of hypertension and is currently on lisinopril. The patient received a seasonal flu vaccine two weeks ago. He has been taking prednisone 20 mg daily for the past three weeks to manage inflammation related to his cancer. The patient denies any history of allergies to medications. He has not received any prior immunotherapy treatments. The patient lives with his wife and has a supportive family network. He is currently able to perform daily activities with some assistance. The patient expresses concern about his prognosis and is interested in exploring treatment options. He is scheduled for a follow-up appointment in two weeks to discuss potential participation in clinical trials.","grade":"Qualified"}
{"patient":{"resourceType":"Patient","id":"NCT06364917-4","identifier":[{"use":"usual","system":"http://example.org/patients","value":"123456789"}],"name":[{"use":"official","family":"Martinez","given":["Daniel"]}],"telecom":[{"system":"phone","value":"555-123-4567","use":"home"},{"system":"email","value":"daniel.martinez@example.com","use":"home"}],"gender":"male","birthDate":"1965-07-15","address":[{"use":"home","line":["123 Elm Street"],"city":"Springfield","state":"IL","postalCode":"62704","country":"USA"}],"maritalStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/v3-MaritalStatus","code":"M","display":"Married"}]},"communication":[{"language":{"coding":[{"system":"urn:ietf:bcp:47","code":"en","display":"English"}]},"preferred":true}]},"fhirResources":[{"resourceType":"Condition","id":"NCT06364917-4-0","clinicalStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/condition-clinical","code":"active","display":"Active"}]},"verificationStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/condition-ver-status","code":"confirmed","display":"Confirmed"}]},"code":{"coding":[{"system":"http://snomed.info/sct","code":"254637007","display":"Non-small cell lung cancer"}]},"subject":{"reference":"Patient/NCT06364917-4"}},{"resourceType":"Observation","id":"NCT06364917-4-1","code":{"coding":[{"system":"http://loinc.org","code":"89269-5","display":"ECOG performance status"}]},"subject":{"reference":"Patient/NCT06364917-4"},"valueCodeableConcept":{"coding":[{"system":"http://snomed.info/sct","code":"0","display":"Fully active"}]}},{"resourceType":"MedicationStatement","id":"NCT06364917-4-2","status":"active","subject":{"reference":"Patient/NCT06364917-4"}}],"patientNote":"Patient is a 58-year-old male with a confirmed diagnosis of stage IV non-small cell lung cancer. He reports occasional shortness of breath and a persistent cough, which has been managed with inhaled bronchodilators. Patient denies any recent infections or fever. He has a history of hypertension, which is well-controlled with medication. No known allergies to medications or foods. Patient has not received any live-virus vaccinations in the past month. He maintains a good level of physical activity, walking daily without assistance. Recent imaging shows stable disease with no new metastases. Blood tests reveal normal liver and kidney function. Patient is currently on a regimen of chemotherapy and reports manageable side effects, primarily mild fatigue. He is compliant with his treatment plan and attends regular follow-up appointments. Patient expresses a positive outlook and is motivated to continue with his current treatment strategy.","grade":"Disqualified"}
{"patient":{"resourceType":"Patient","id":"NCT06364917-2","identifier":[{"use":"usual","system":"http://example.org/patients","value":"123456789"}],"name":[{"use":"official","family":"Brown","given":["Carol"]}],"telecom":[{"system":"phone","value":"555-123-4567","use":"home"},{"system":"email","value":"carol.brown@example.com","use":"home"}],"gender":"female","birthDate":"1965-07-20","address":[{"use":"home","line":["123 Main St"],"city":"Springfield","state":"IL","postalCode":"62701","country":"USA"}],"maritalStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/v3-MaritalStatus","code":"M","display":"Married"}]},"communication":[{"language":{"coding":[{"system":"urn:ietf:bcp:47","code":"en","display":"English"}]},"preferred":true}]},"fhirResources":[{"resourceType":"Condition","id":"NCT06364917-2-0","clinicalStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/condition-clinical","code":"active","display":"Active"}]},"verificationStatus":{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/condition-ver-status","code":"confirmed","display":"Confirmed"}]},"category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/condition-category","code":"encounter-diagnosis","display":"Encounter Diagnosis"}]}],"code":{"coding":[{"system":"http://snomed.info/sct","code":"254637007","display":"Non-small cell lung cancer"}]},"subject":{"reference":"Patient/NCT06364917-2"},"onsetDateTime":"2023-01-15"},{"resourceType":"Observation","id":"NCT06364917-2-1","status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory","display":"Laboratory"}]}],"code":{"coding":[{"system":"http://loinc.org","code":"1975-2","display":"ECOG performance status"}]},"subject":{"reference":"Patient/NCT06364917-2"},"effectiveDateTime":"2023-10-01","valueCodeableConcept":{"coding":[{"system":"http://loinc.org","code":"LA9623-3","display":"ECOG performance status 1"}]}},{"resourceType":"MedicationStatement","id":"NCT06364917-2-2","status":"active","subject":{"reference":"Patient/NCT06364917-2"},"effectivePeriod":{"start":"2023-09-15"}}],"patientNote":"Patient is a 58-year-old female with a confirmed diagnosis of stage IV non-small cell lung cancer. She presents with a persistent cough and mild shortness of breath, which have been gradually worsening over the past few months. The patient reports occasional fatigue but denies any significant weight loss or night sweats. She has a history of hypertension, which is well-controlled with medication. The patient is currently on a chemotherapy regimen including Carboplatin, which she tolerates well with minimal side effects. Her ECOG performance status is 1, indicating she is restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature. Recent imaging shows stable disease with no new metastases. The patient has not received any live-virus vaccinations in the past month and has no known allergies to medications. She is compliant with her treatment plan and follows up regularly with her oncology team. The patient expresses a positive outlook and is motivated to continue her current treatment regimen. She has a supportive family and reports no issues with accessing healthcare services.","grade":"Qualified"}
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